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Research Scientist III, Mass Spectrometry
Temporary to Full Time
Apex Life Sciences is currently recruiting for a Mass Spectrometry Research Scientist III position in Buffalo, NY.
Major Duties and Responsibilities:
Analysis and interpretation of assay development, high throughput screening, potency and mass spectrometry data
Analysis of recombinant protein and antibody drug conjugate samples
Potency and selectivity testing
Automation of assays and high throughput screening by mass spectrometry
Setup and validation of high throughput sample preparation procedures and MS-based assays for the identification of pharmacologically active compounds
Experience developing biochemical and MS assays for high throughput analysis by MALDI-TOF, MALDI-TOF/TOF and SPE-MS/MS is preferred
Demonstrate substantial expertise in mass spectrometry and biochemical methods development and the preparation of various forms of biological sample for small molecule and/or protein mass spectrometry.
Become self-sufficient in the setup, programming and use of all hardware and software provided for the development, validation, analysis, execution and documentation of screening by mass spectrometry assays within 4 months of arrival.
Assist in the development and validation of protocols and assays for the analysis of protein and cellular samples in low and high throughput.
Assist in the development and validation of bioactivity assays and their transfer to automated equipment including mass spectrometers and liquid handling robotics.
Troubleshooting of automated equipment and data analysis templates.
Analysis and appropriate interpretation of experimental data. Collation of data and recommendations as reports and presentations for internal and external clients.
Assistance in the preparation of project proposals and associated budgets.
Effective communication in verbal and written form on results, issues, recommendations and plans.
Manage workload and time to perform multiple projects effectively, and ensure all necessary paperwork is completed on a timely basis.
Education and/or Experience:
M.S. or B.Sc. in Analytical Chemistry, or other applicable natural science field, including biology or equivalent industrial experience
Experience operating and maintaining mass spectrometry equipment (MALDI-MS/MS, LC-MS/MS, TOF or an equivalent MS technology for quantitative analysis of complex biological solutions) and interpreting mass spectrometry data.
Demonstrated ability to independently develop MS analysis methods.
Experience in the application of high throughput MS to the screening of compound libraries and identification of pharmacologically active compounds is preferred.
The employee must regularly lift and/or move up to 10 pounds and occasionally lift and/or move up to 50 pounds
Specific vision abilities required by this job include close vision, color vision, depth perception, and ability to adjust focus
Incumbent may be required to obtain/qualify for and maintain the clearance to wear a respirator at a “class B” level or above following OSHA mandated guidelines.