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Senior Research Scientist I, Assay Development & Screening

 

 

Company Overview

Senior Research Scientist I - Assay Development & Screening in Buffalo, NY

 

The company provides global contract research and manufacturing services to the pharmaceutical and biotechnology industries.

Job Description

The Senior Research Scientist I is a specialist in the development and execution of screening assays for the identification, optimization and characterization of pharmacologically active compounds. They are expected to work independently and collaboratively as a member of a team to establish assays, demonstrate their suitability for intended purpose, execute high throughput screening campaigns and compound testing cascades for lead optimization programs. They are expected to routinely demonstrate problem solving skills and high levels of proficiency, professionalism and productivity. They will be recognized by peers and supervisors as a technical expert.

The Senior Research Scientist I will work independently on complex tasks and are expected to generate ideas for and provide recommendations to drug discovery projects. This requires comprehension of current literature, therapeutic areas and the drug discovery process. Specific duties include: development of reagents and assays for testing of natural product and synthetic samples; automation of assays and high throughput screening; trouble shooting of automated equipment and data analysis templates; potency, selectivity & mechanism of action (“MOA”) testing; analysis and interpretation of assay development, high throughput screening, potency, selectivity & MOA data; collation of data and drafting of reports for circulation to customers.

The Senior Research Scientist I is self motivated, continually demonstrates initiative in handling responsibilities, solves problems and strives to do their job better.  Major components of the scientist's performance rating will be based on productivity, analytical competence and experimental decision making. Supervision of other researchers may be required.

RESPONSIBILITIES

  • Development of a working knowledge of a wide variety of technologies related to reagent production, bioassays, screening, automation and drug discovery
  • Display of a high level of expertise in assay development, automation and selection of actives
  • Act as a technical consultant; volunteer suggestions on assay technologies, automation strategies and reagent procurement. Perform literature searches to collect information from a spectrum of sources
  • Use of sound judgment, acquired knowledge and experience to develop new reagents, assays, protocols and strategies for the identification and prioritization of active samples. These tasks will often require extensive literature searching, as well as contact with suppliers and customers, etc
  • Recommend and implement methods to increase the quality of products and services
  • Adapt to changing priorities such that productivity and efficiency are unaffected
  • Organize work time so that several projects are run concurrently
  • Work closely with other scientists to coordinate project progress and the use of resources
  • Develop expertise in the programming, testing and validation of automated equipment and data analysis templates. The scientist will be able to write and test complex equipment and analysis procedures under minimal supervision
  • Development of reagents and assays for bioactivity screening and their transfer to robotic systems for high throughput and low throughput screening
  • Performance of high throughput and secondary screening of sample collections and generation of high quality screening data
  • Analysis and interpretation of assay development, high throughput screening, potency, selectivity and MOA data
  • Development and effective application of a broad spectrum of practical laboratory skills; including molecular biology, cell culture, biochemistry, assay development, in depth analysis of bioactivity data and the use of automated equipment
  • Conduct laboratory operations in a safe manner.  Maintain familiarity with the Chemical Hygiene Plan and the Biosafety, Blood Borne Pathogen and Radiation Safety Procedures provided by the company. Exhibit safety awareness and safe work practices.
  • Effectively utilize and teach the use of standard laboratory equipment including hand pipettes, balances, pH meters, plate readers and calculators.
  • Use and maintain equipment in a neat and orderly manner.  Report any malfunction immediately to supervisor. 
  • Practice preventative maintenance on laboratory equipment and replenish laboratory supplies as stock is depleted to prevent “down-time”.
  • Keep accurate, legible and complete records of all experiments and observations. Record all appropriate data electronically in the company databases.
  • Submit acceptable written periodic reports.  Prepare summaries of experimental findings reliably and independently.
  • Discuss routinely with supervisor the status of assigned programs and potential problems
  • Communicate orally and in writing unexpected occurrences which could adversely affect established timetables.
  • Manage workload and time to enable the incumbent to perform multiple projects effectively, and ensure all necessary paperwork is completed on a timely basis.
  • Follow responsible actions regarding chemical, radiological and biological disposal.  Maintain compliance with all regulations at the federal, state, and local levels.

JOB REQUIREMENTS

 

  • Education and/or Experience
  • Bachelors, Masters or Doctorate Degree with a major in Biology or Biochemistry.  Candidates with a Doctoral degree should have a minimum of two to three years of relevant, post doctoral, industrial experience.
  • Experience in a pharmaceutical discovery research setting, applying advanced assay development, screening and data analysis techniques is required.
  • Computer training including use of software associated with data analysis and screening
  • Other pertinent training/courses

Shift:  Standard 8

 

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